Lung Dendritic Cells Rapidly Mediate Anthrax Spore Entry through the Pulmonary Route
نویسندگان
چکیده
منابع مشابه
Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route.
Inhalational anthrax is a life-threatening infectious disease of considerable concern, especially because anthrax is an emerging bioterrorism agent. The exact mechanisms leading to a severe clinical form through the inhalational route are still unclear, particularly how immobile spores are captured in the alveoli and transported to the lymph nodes in the early steps of infection. We investigate...
متن کاملAnthrax toxin entry into polarized epithelial cells.
We examined the entry of anthrax edema toxin (EdTx) into polarized human T84 epithelial cells using cyclic AMP-regulated Cl- secretion as an index of toxin entry. EdTx is a binary A/B toxin which self assembles at the cell surface from anthrax edema factor and protective antigen (PA). PA binds to cell surface receptors and delivers EF, an adenylate cyclase, to the cytosol. EdTx elicited a stron...
متن کاملResident CD11c+ lung cells are impaired by anthrax toxins after spore infection.
Bacillus anthracis secretes 2 toxins: lethal toxin (LT) and edema toxin (ET). We investigated their role in the physiopathologic mechanisms of inhalational anthrax by evaluating murine lung dendritic cell (LDC) functions after infection with B. anthracis strains secreting LT, ET, or both or with a nontoxinogenic strain. Three lung cell populations gated on CD11c/CD11b expression were obtained a...
متن کاملRole of lung dendritic cells in acute pulmonary inflammation
s and oral presentations from PhD thesis von Wulffen, W., J. Lohmeyer, W. Seeger, and U.A. Maus. 2005. Flt3L elicited lungdendritic cells are recruited via β2 integrin dependent pathways and amplify the lunginflammatory response to LPS. Jahrestagung der Sektion der Zellbiologie derDeutschen Gesellschaft für Pneumologie, Bonn; Oct. 25 , 2005 von Wulffen, W., J. Lohmeyer, W. Seeger, a...
متن کاملAmiodarone and bepridil inhibit anthrax toxin entry into host cells.
Anthrax lethal toxin is one of the fundamental components believed to be responsible for the virulence of Bacillus anthracis. In order to find novel compounds with anti-lethal toxin properties, we used a cell-based assay to screen a collection of approximately 500 small molecules. Nineteen compounds that blocked lethal toxin-mediated killing of RAW 264.7 macrophages were identified, and we repo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Immunology
سال: 2007
ISSN: 0022-1767,1550-6606
DOI: 10.4049/jimmunol.178.12.7994